Leadership

Senthil works as a Global Manager—Toxicology, Risk Assessment and Product Safety in Eastman Chemical Company, where he leads a diverse global team of toxicologists, ecotoxicologists, and risk assessors. He is accountable for product safety and compliance of all corporate business units, and support advocacy efforts on new and emerging chemical regulations globally. Prior to joining Eastman, he worked at Lubrizol Corporation where he managed toxicology and ecotoxicology studies; performed human health, environmental and exposure risk assessments; provided expertise for hazard communication and global compliance. Senthil started his professional career at United States Environmental Protection Agency (US EPA) and Centers for Disease Control and Prevention (CDC) where he conducted critical review of toxicology data and developed integrated risk assessment for chemicals of agencies interest.

Senthil served in various officer’s roles and recognized with honors and awards from Society of Toxicology, American College of Toxicology, and Environmental Mutagenesis and Genomics Society. In SOT, Senthil is currently serving as a Councilor—Southeast Regional Chapter; he also served as a Councilor—Ohio Valley Regional Chapter; Postdoctoral Representative—Regulatory and Safety Evaluation Specialty Section, Membership Committee, Continuous Education Course Committee, Committee on Diversity Initiatives; Peer Mentor—Undergraduate Education Program; Graduate Student Representative—Student Advisory Council. Senthil is a trained Veterinarian having PhD in Human Toxicology. He is also a Diplomate of the American Board of Toxicology, and a European Registered Toxicologist.

Claire joined IDEAYA Biosciences as the Head of Toxicology in 2017, and, in her current role, she is responsible for the strategic direction of Nonclinical Safety and Pharmacology activities to support the entire portfolio of IDEAYA molecules. In addition, she has served as a Project Team Lead for two assets in IDEAYA’s portfolio. Prior to joining IDEAYA, Claire served as a Project Toxicologist and a Project Team Lead at Gilead Sciences, where she was responsible for Nonclinical Safety for small and large molecules indicated for oncology, inflammation, and anti-viral diseases. Claire also worked for 12 years at Incyte, where through increasing positions of responsibility, she contributed to, or led, the Nonclinical Safety strategy for multiple small molecules, two of which are now approved drugs.

Claire received her BSc (Hons) in Medicinal and Pharmaceutical Chemistry and PhD in Pharmacology from the University of Loughborough in the UK. During her PhD, Claire spent time as a visiting graduate student at the University of Michigan, and she completed a postdoctoral fellowship at Memorial Sloan Kettering Cancer Center in New York. Claire obtained the Diplomate of the American Board of Toxicology in 2012. Claire has been a member of SOT since 2007 and has served in the following capacities: NorCal SOT VP-Elect/VP (2022/2023), WIT Program Review Committee (2018–2021), WIT Awards Committee (2018), WIT SOT Awards Nomination Committee (2022), RSESS Program Review Committee (2019–2020, Co-Chair 2021; Chair 2022/2023), RSESS VP-Elect (2023), and SOT Mentor Match program (2021–2023).

Dr. Aggarwal is currently serving as a global preclinical safety lead at Merck & Co. (AH Business), and he has accumulated over 15 years of expertise in the field of regulatory toxicology. He holds a veterinary medicine degree and a PhD in pharmacology and toxicology from India. Following his studies, he spent four years as a research scientist at a WHO collaborative research center in Germany. He later transitioned to the chemical and pesticide industry, working as a global regulatory toxicologist for Dow Chemicals in the UK from 2010 to 2018 and in the US from 2018 to 2022. More recently, he has joined the animal health industry.

Dr. Aggarwal’s work has spanned various cultural and geographical contexts, involving interactions with regulatory agencies in both developed countries such as the US and across the EU, as well as developing nations like China, India, and Brazil. Dr. Aggarwal has played a significant role in shaping regulatory guidelines and standards. His leadership on multiple projects has led to the establishment and/or update of guidance documents issued by organizations across Europe and New Zealand and the OECD. He has obtained the European Registered Toxicologist (ERT) and the American Board of Toxicology (DABT) certifications, highlighting his expertise and recognition in the field.

In addition to his research and regulatory work, Dr. Aggarwal has authored more than 25 papers that have been published in reputable journals focusing on regulatory toxicology and pharmacology. He has engaged in collaborations with scientists from academia, industry, and government sectors, cultivating a diverse network within the field.

Dr. Aggarwal’s involvement in various scientific conferences and workshops worldwide demonstrates his commitment to knowledge sharing and collaboration. He has organized sessions and workshops at prominent events such as the IUTOX International Conference, SOT Annual Meeting, EUROTOX Annual Congress, ASIATOX International Congress, STOX (India) Conference, and SBTOX (Brazil) Congress. As an active member of the Society of Toxicology for over a decade, he has not only participated in Annual Meetings but has also undertaken outreach initiatives on behalf of SOT Special Interest Groups. Overall, Dr. Aggarwal’s broad range of experiences, extensive network, and dedication to global collaboration position him well to contribute to the organization of international events and facilitate collaborations to address common challenges in regulatory safety evaluation.

Dr. Sapiro is a project toxicologist at Blueprint Medicines Corporation where she supports discovery and development stage programs in Oncology. Previously, she was a project toxicologist at Takeda Development Center Americas, Inc supporting programs in Oncology, Gastrointestinal, and Rare Disease therapeutic areas. Jessica also held toxicology roles of increasing responsibility at Sage Therapeutics and Allergan. Jessica received her PhD in Pharmacology and Toxicology from the University of Arizona. She presented multiple papers at national meetings and received several awards for her research on All-Trans-Retinoic Acid protection against acute kidney injury. Prior to pursuing her PhD, Jessica worked at Alnylam Pharmaceuticals where she participated in building investigative toxicology capabilities and provided nonclinical study support. Jessica has been a member of the Society of Toxicology (SOT) since 2011, is a member of the American College of Toxicology, and is a Diplomate of the American Board of Toxicology.

She is an active member of SOT and has been part of the Regulatory and Safety, Biotechnology, Drug Discovery, Mechanisms, and Ocular Specialty sections, multiple regional chapters, and the Women in Toxicology (WIT) special interest group. Jessica currently serves on the Education Career Development Committee (ECDC) (2020-present) and led the launch of the updated SOT Mentor Match Program. She served the Women in Toxicology Special Interest Group (Councilor 2018–2020, Student Representative 2014–2016), Mentoring Task Force Committee Member (2018–2020), Graduate Student Leadership Committee from 2014–2017 (Professional Development Secretary 2015–2016 and Chair 2016–2017). Jessica served as a mentor for the Committee on Diversity Initiatives Undergraduate Education Program for several years and as a facilitator for the SOT Mentoring Breakfast in 2018. She is currently a Councilor for RSESS.

Dr. Sheevers received her PhD in Pharmacology and Toxicology from the University of Arizona in 1994, under the advisement of Dr. A. Jay Gandolfi. Dr. Sheevers joined the US FDA in 1995, where she was a reviewer and then a supervisor in the Center for Drugs. After US FDA, Dr. Sheevers was an active consultant in drug development across indications, for both small and large molecules. She co-founded the women-owned and diverse consulting firm Aclairo in 2001, which she presided over as president or executive vice president for 16 years. Some of her most compelling projects included drugs for rare diseases including Dravet Syndrome, Huntington’s Disease and sickle cell anemia, and break through drugs in the areas of pulmonary, oncology and neuropharmacology. In 2016, Aclairo was sold to EPL, Inc. an employee-owned company specializing in veterinary pathology. Dr. Sheevers retired from EPL, Inc. in May 2020, and continues to actively work in the drug development arena. She remains an active member of the Society of Toxicology and the American College of Toxicology, where she has organized many sessions and presentations.

Dr. William Klaren is a board-certified toxicologist at ToxStrategies where he assists clients in systematic review, publication reliability, and consumer product risk assessments specializing in pesticide and cosmetic products. He received his doctorate in Human Toxicology from the University of Iowa in 2016 and was a Postdoctoral Research Fellow at Texas A&M University from 2016–2018. During his postdoctoral research, he developed and validated in vitro multiplexed high-throughput organotypic assays to assist in bioactivity profiling and read-across endeavors. Before joining ToxStrategies, Dr. Klaren was a Senior Associate in Toxicology at the consumer goods company, S.C. Johnson and Son, Inc. where he performed consumer goods risk assessments and supported pesticidal product registrations under the US EPA and the EU BPR. While at S.C. Johnson, Dr. Klaren also served as an advocate for several insecticidal active ingredients by sitting on industrial task forces where he helped address regulatory and toxicological issues. He is the author / co-author of 17 peer-reviewed publications ranging from several in vivo mechanistic investigations to comparative analyses of in vitro bioactivity data and in vivo transcriptomic concordance. He has been a member of SOT since 2012. During that time, he has been involved with several specialty sections (In Vitro and Alternative Methods (IVAM), Mixtures, and Risk Assessment Specialty Sections (RASS)) as well as the Central States and Midwest Regional Chapters. Lastly, Dr. Klaren has engaged with students and younger toxicologists via mentoring events and guesting lecturing opportunities.

Dr. You most recently served as a project toxicologist at Takeda Pharmaceuticals in San Diego, where she represented Drug Safety Research and Evaluation in a project team and drove the nonclinical safety assessment strategies of drug candidates at discovery and development stages to identify and mitigate potential toxicity liabilities. Previously, Dr. You was a postdoctoral fellow in the Division of National Toxicology Program at the National Institute of Environmental Health Sciences (NIEHS), where she worked on two Tox21 federal interagency collaborative projects that aimed to understand and quantify how genetic variation between individuals or cell lines can influence an individual’s susceptibility to toxicity upon chemical exposure. Dr. You obtained her Doctor of Pharmacy in 2014 and Doctor of Philosophy in toxicology in 2019, both at Rutgers University, where she investigated the epigenetic regulation of multidrug resistance 1 and breast cancer resistance protein transporters at the blood-brain barrier. Dr. You has published multiple papers and given numerous podium and poster presentations on her research at local, national, and international meetings and received several awards for her works, including the 2021 RSESS Postdoc Excellence Award.

Dr. You has been an active member of SOT and a leader in various professional organizations. She is currently serving as the Secretary/Treasurer for the SOT Korean Toxicologists Association in America Special Interest Group and as a member of the SOT Inclusion, Diversity, and Engagement Committee (IDEC). Previously, Dr. You served as Postdoctoral Representative for the Mechanisms Specialty Section and the SOT Continuing Education Committee; Councilor for the SOT Postdoctoral Assembly; Graduate Student Representative for the Division of Toxicology at ASPET; and a member of the Podcast Committee at the American College of Toxicology.

Dr. Carter is a postdoctoral fellow at the University of South Carolina School of Medicine, where he studies the effects of cannabinoids on bone marrow differentiation, with a focus on myeloid differentiation. He received his doctorate in molecular genetics from the University of South Carolina in 2021 where he studied the effects of heavy metals on bacterial gene expression. Dr. Carter is a part of the Cannabinoid Science Work Group for The Washington State Liquor and Cannabis Board. He is an author / co-author of 4 peer-reviewed articles. He has been a member of the SOT since 2021.

Olivia Lampe is a PhD trainee in Toxicology at Texas A&M University working as a graduate researcher in Dr. Natalie Johnson’s lab. Olivia’s projects are centered around assessing the adverse effects of ambient air pollution on respiratory health. Her interests revolve around a shared goal of improving in vitro hazard assessment for inhalation exposures. Her current projects include particulate matter, volatile organic compounds, and the air liquid interface system for in vitro exposures. Olivia completed a Mickey Leland Internship in 2023 at the Texas Commission of Environmental Quality (TCEQ) which is the state level regulatory agency for Texas. She encourages student engagement in her PhD program’s journal club by seeking out diverse faculty and alumni as guest speakers. She has been a member of SOT since 2022.